Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.58 |
| ▸ | MEN1 | O00255 | 11/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480671 | 0.85 | TRPA1 (0.58) | KMT2AMEN1RAB9ANPC1ABL1 | |
| SCHEMBL21586296 | 0.83 | KMT2A (0.74) | KMT2AMEN1RAB9AHDAC1HDAC6 | |
| SCHEMBL13190714 | 0.82 | KMT2A (0.65) | KMT2AMEN1RAB9ALMNAMAPK1 | |
| SCHEMBL480598 | 0.82 | TRPA1 (0.61) | KMT2AMEN1RAB9ANPC1ABL1 | |
| SCHEMBL4408570 | 0.82 | GAA (0.61) | KMT2AMEN1RAB9ANPC1HDAC1 | |
| SCHEMBL611935 | 0.81 | KMT2A (0.51) | KMT2AMEN1RAB9ALMNAMAPK1 | |
| SCHEMBL480758 | 0.81 | MAPT (0.71) | KMT2AMEN1RAB9ANPC1ABL1 | |
| SCHEMBL10288914 | 0.80 | MEN1 (0.65) | KMT2AMEN1RAB9AABL1HDAC1 | |
| SCHEMBL2455704 | 0.80 | ABL1 (0.72) | KMT2AMEN1ABL1LMNA | |
| SCHEMBL4410636 | 0.80 | MAPT (0.70) | KMT2AMEN1RAB9ANPC1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |