Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.61 |
| ▸ | MGAM | O43451 | 7/20 | 0.61 |
| ▸ | SI | P14410 | 7/20 | 0.61 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | WNT3A | P56704 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487938 | 0.89 | GAA (0.61) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL7930002 | 0.87 | GAA (0.60) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL21586296 | 0.87 | KMT2A (0.74) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL480758 | 0.87 | MAPT (0.71) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL2452315 | 0.87 | ELOVL1 (0.72) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL4410636 | 0.86 | MAPT (0.70) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL4420194 | 0.86 | HDAC1 (0.65) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL10921733 | 0.85 | KMT2A (0.68) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL4416778 | 0.85 | RAB9A (0.63) | KMT2AMAPTMEN1LMNAWNT3A | |
| SCHEMBL4408791 | 0.84 | LMNA (0.57) | KMT2AMAPTALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012166891-A2 | MU-OPIOID RECEPTOR BINDING COMPOUNDS | ALGYNOMICS INC. (US) | 2012-12-06 | — | — | WO | disclosed |
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |