Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | DRD1 | P21728 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411918 | 0.86 | DRD2 (0.61) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL4431761 | 0.83 | DRD2 (0.57) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL4431750 | 0.83 | DRD2 (0.57) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL31266584 | 0.80 | DRD2 (0.53) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL31266637 | 0.77 | DRD2 (0.50) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL3410493 | 0.77 | CHRM1 (0.74) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL3429019 | 0.75 | CHRM1 (0.67) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL29969899 | 0.74 | DRD2 (0.74) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL167601 | 0.74 | DRD2 (0.74) | DRD2HTR2ACHRM2CHRM4CHRM5 | |
| SCHEMBL141985 | 0.74 | HRH4 (0.71) | DRD2HTR2ACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517871-B2 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | ACADIA PHARMACEUTICALS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20060199798-A1 | Amino bustituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | EK FREDRIK | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199798-A1 | Amino bustituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | OPRL1, CHRM4, CNR1 | DRD2 26/4885HTR2A 46/4885CHRM2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.