Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1849293 | 0.81 | BACE1 (0.50) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL1853608 | 0.77 | ALDH1A1 (0.49) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL1852416 | 0.76 | HPGD (0.58) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL1852128 | 0.72 | HPGD (0.55) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL1852418 | 0.72 | HPGD (0.53) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL1850906 | 0.70 | HPGD (0.58) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL1851896 | 0.70 | KMT2A (0.52) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL1852060 | 0.69 | ESR2 (0.49) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL13699752 | 0.69 | NPC1 (0.55) | ALDH1A1HPGDKMT2ATSHRHSD17B10 | |
| SCHEMBL29827670 | 0.69 | ALDH1A1 (0.76) | ALDH1A1HPGDKMT2ATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |