Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18687290 | 0.82 | AAK1 (0.47) | POLBAAK1MAPK1SMN1; SMN2PKM | |
| SCHEMBL28800785 | 0.82 | AAK1 (0.47) | POLBAAK1MAPK1SMN1; SMN2PKM | |
| SCHEMBL4088981 | 0.82 | ATM (0.49) | POLBSMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL9471506 | 0.78 | KDM4E (0.51) | POLBSMN1; SMN2ALDH1A1KDM4ETSHR | |
| SCHEMBL29902875 | 0.78 | HTT (0.53) | POLBAAK1MAPK1SMN1; SMN2PKM | |
| SCHEMBL2129974 | 0.78 | AAK1 (0.42) | POLBAAK1MAPK1SMN1; SMN2PKM | |
| SCHEMBL2715770 | 0.78 | AAK1 (0.42) | POLBAAK1MAPK1SMN1; SMN2PKM | |
| Water SCHEMBL29902298 | 0.76 | AAK1 (0.41) | POLBAAK1MAPK1SMN1; SMN2PKM | |
| Water SCHEMBL29947214 | 0.76 | AAK1 (0.41) | POLBAAK1MAPK1SMN1; SMN2PKM | |
| SCHEMBL3714585 | 0.75 | ALDH1A1 (0.50) | AAK1MAPK1SMN1; SMN2PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663291-B1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | KARYOPHARM THERAPEUTICS INC (US) | 2024-12-18 | — | — | EP | disclosed |
| EP-2858991-A2 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics, Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013170068-A2 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | KARYOPHARM THERAPEUTICS, INC. (US) | 2013-11-14 | — | — | WO | disclosed |
| CN-100587001-C | Polyacetal resin composition | POLYPLASTICS CO | 2010-02-03 | — | — | CN | disclosed |
| US-7638565-B2 | Polyacetal resin composition | POLYPLASTICS CO., LTD. (JP) | 2009-12-29 | — | — | US | disclosed |
| US-20070054998-A1 | Polyacetal resin composition | POLYPLASTICS CO., LTD. (JP) | 2007-03-08 | — | — | US | disclosed |
| CN-1878834-A | Polyacetal resin composition | POLYPLASTICS CO (JP) | 2006-12-13 | — | — | CN | disclosed |
| EP-1686156-A1 | POLYACETAL RESIN COMPOSITION | Polyplastics Co., Ltd. (JP) | 2006-08-02 | — | — | EP | disclosed |
| EP-1296961-A1 | 1,4-DIAZEPAN-2,5-DIONE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090083-A1 | 1,4-DIAZEPAN-2,5-DIONE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |
| US-4593027-A | 3-aryl-7-chloro-3,4-dihydroacridine-1,9(2H,10H)-dione 1-oximes and 1-hydrazone derivatives, their salts, a process for their preparation, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-06-03 | — | — | US | disclosed |