Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28800785 | 0.79 | AAK1 (0.47) | MAPK1AAK1ALDH1A1LMNAMAPT | |
| SCHEMBL18687290 | 0.79 | AAK1 (0.47) | MAPK1AAK1ALDH1A1LMNAMAPT | |
| SCHEMBL18612438 | 0.79 | HTT (0.46) | HTTMAPK1ALDH1A1LMNAMAPT | |
| SCHEMBL6678936 | 0.79 | SIGMAR1 (0.58) | HTTMAPK1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4419679 | 0.78 | POLB (0.54) | MAPK1AAK1ALDH1A1LMNAMAPT | |
| SCHEMBL19022016 | 0.77 | SIGMAR1 (0.43) | MAPK1ALDH1A1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL30067025 | 0.77 | TSHR (0.47) | HTTMAPK1AAK1ALDH1A1TSHR | |
| SCHEMBL7969101 | 0.76 | ALDH1A1 (0.46) | HTTMAPK1AAK1ALDH1A1LMNA | |
| SCHEMBL12283489 | 0.76 | ALDH1A1 (0.46) | HTTMAPK1AAK1ALDH1A1LMNA | |
| SCHEMBL21251239 | 0.75 | HTT (0.41) | HTTMAPK1AAK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11661419-B2 | Benzimidazole derivative compounds and uses thereof | PFIZER INC. (US) | 2023-05-30 | — | — | US | claimed |
| CN-115087655-A | Benzimidazole derivatives | 辉瑞公司 | 2022-09-20 | — | — | CN | claimed |
| US-20240124439-A1 | Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease | PFIZER INC. (US) | 2024-04-18 | — | — | US | disclosed |
| EP-4077316-A1 | BENZIMIDAZOLE DERIVATIVES | Pfizer Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087655-A | Benzimidazole derivatives | 辉瑞公司 | 2022-09-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124439-A1 | Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease | ITK, PDXK, HRH4 | HTT 4786/4885MAPK1 955/4885AAK1 457/4885 |
| US-11661419-B2 | Benzimidazole derivative compounds and uses thereof | ITK, HRH4, BLK | HTT 4108/4885MAPK1 1399/4885AAK1 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.