Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415270 | 0.86 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL4317080 | 0.86 | KDM4E (0.56) | ALDH1A1LMNAKDM4EL3MBTL1HPGD | |
| Hydrochloric Acid SCHEMBL4331030 | 0.85 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL4415954 | 0.85 | ALDH1A1 (0.62) | ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL3413244 | 0.84 | KIT (0.55) | KIT | |
| SCHEMBL3410527 | 0.83 | GRM5 (0.59) | KITALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL4324240 | 0.81 | KIT (0.49) | KITALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL3413404 | 0.81 | NAMPT (0.47) | KITALDH1A1LMNAKDM4E | |
| SCHEMBL4417361 | 0.81 | SLC6A7 (0.56) | ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL4426054 | 0.81 | TACR2 (0.57) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | KIT 4444/4885SIGMAR1 413/4885ALDH1A1 3104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.