Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419941 | 0.91 | PTPN1 (0.46) | CAPN1PTPN1EPHX2 | |
| SCHEMBL10036462 | 0.90 | PTPN1 (0.49) | CTSKCAPN1PTPN1EPHX2 | |
| SCHEMBL2632575 | 0.90 | PTPN1 (0.49) | CTSKCAPN1PTPN1EPHX2 | |
| SCHEMBL4418954 | 0.89 | PTPN1 (0.46) | CTSKCAPN1PTPN1EPHX2CTSL | |
| SCHEMBL4598817 | 0.88 | KMT2A (0.49) | MDM2MAPTSMN1; SMN2EPHX2 | |
| SCHEMBL4598821 | 0.88 | KMT2A (0.49) | MDM2MAPTSMN1; SMN2EPHX2 | |
| SCHEMBL9449368 | 0.87 | PTPN1 (0.51) | CTSKPTPN1EPHX2 | |
| SCHEMBL4885335 | 0.87 | TLR2 (0.49) | MDM2MAPTSMN1; SMN2PTPN1EPHX2 | |
| SCHEMBL4599971 | 0.87 | TLR2 (0.49) | MDM2MAPTSMN1; SMN2PTPN1EPHX2 | |
| SCHEMBL4600383 | 0.85 | TLR2 (0.54) | MDM2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691845-A4 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1691845-A1 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | Bristol-Myers Squibb Pharma Company (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005023314-A1 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-03-17 | — | — | WO | disclosed |