Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419945 | 0.91 | CTSK (0.50) | PTPN1EPHX2CAPN1 | |
| SCHEMBL2632575 | 0.89 | PTPN1 (0.49) | PTPN1EPHX2CAPN1 | |
| SCHEMBL10036462 | 0.89 | PTPN1 (0.49) | PTPN1EPHX2CAPN1 | |
| SCHEMBL4418954 | 0.88 | PTPN1 (0.46) | PTPN1EPHX2CAPN1MDM4TP53 | |
| SCHEMBL9449368 | 0.86 | PTPN1 (0.51) | PTPN1EPHX2MDM4TP53CASP3 | |
| SCHEMBL16285991 | 0.84 | PTPN1 (0.48) | PTPN1CAPN1MDM4TP53 | |
| SCHEMBL14264914 | 0.83 | PTPN1 (0.52) | PTPN1MDM4TP53CASP3 | |
| SCHEMBL19280962 | 0.82 | CASP3 (0.54) | EPHX2MDM4TP53CASP3 | |
| SCHEMBL29700028 | 0.82 | PTPN1 (0.56) | PTPN1MDM4TP53CASP3 | |
| SCHEMBL29531966 | 0.82 | PTPN1 (0.53) | PTPN1CAPN1MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691845-A4 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1691845-A1 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | Bristol-Myers Squibb Pharma Company (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005023314-A1 | COMPOUNDS CONTAINING MATRIX METALLOPROTEINASE SUBSTRATES AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-03-17 | — | — | WO | disclosed |