SCHEMBL4420089

SCHEMBL4420089

CC(C)(C)OC(=O)N1CCC(OCCc2nc(-c3ccc(S(C)(=O)=O)c(F)c3)no2)CC1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 18/20 0.69
HDAC4 P56524 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10476591 0.95 GPR119 (0.67) GPR119HDAC4
SCHEMBL10476551 0.93 GPR119 (0.59) GPR119HDAC4
SCHEMBL4415852 0.92 GPR119 (0.70) GPR119HDAC4
SCHEMBL4425890 0.88 GPR119 (0.58) GPR119HDAC4
SCHEMBL4415575 0.87 GPR119 (0.55) GPR119HDAC4
SCHEMBL13598326 0.85 GPR119 (0.66) GPR119HDAC4
SCHEMBL4422209 0.85 GPR119 (0.67) GPR119HDAC4
SCHEMBL4107590 0.84 GPR119 (0.69) GPR119HDAC4
SCHEMBL4414094 0.84 GPR119 (0.66) GPR119HDAC4
SCHEMBL4100908 0.83 GPR119 (0.56) GPR119HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2013201-B1 HETEROCYCLIC GPCR AGONISTS PROSIDION LTD (GB) 2012-07-25 EP claimed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
WO-2007003960-A1 GPCR AGONISTS PROSIDION LIMITED (GB) 2007-01-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090325924-A1 GPCR Agonists GPR119, GCGR, GPR27 GPR119 1/4885HDAC4 2550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.