Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GRN | P28799 | 2/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521660 | 0.78 | ALDH1A1 (0.40) | KDM4EGRNSORT1MAPK14MAPT | |
| SCHEMBL432964 | 0.77 | KDM4E (0.50) | KDM4EGRNSORT1MAPK14MAPT | |
| SCHEMBL4415838 | 0.76 | CYP1A2 (0.53) | KDM4EGRNSORT1MAPK14MAPT | |
| SCHEMBL1257733 | 0.73 | KDM4E (0.36) | KDM4EGRNSORT1MAPK14 | |
| SCHEMBL574076 | 0.71 | RAB9A (0.42) | KDM4EALDH1A1LMNANPC1RAB9A | |
| SCHEMBL16055493 | 0.70 | KDM4E (0.34) | KDM4EGRNSORT1NPC1RAB9A | |
| SCHEMBL5879683 | 0.69 | KDM4E (0.39) | KDM4EGRNSORT1ALDH1A1PKM | |
| SCHEMBL4424874 | 0.69 | LRRK2 (0.41) | KDM4EGRNSORT1 | |
| SCHEMBL15942241 | 0.66 | PLA2G10 (0.49) | KDM4EMAPTALDH1A1LMNAPIM3 | |
| SCHEMBL12011404 | 0.66 | BAZ2B (0.39) | KDM4EGRNSORT1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | disclosed |