Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14149490 | 0.86 | NPC1 (0.62) | NPC1RAB9AKDM4EALDH1A1HRH3 | |
| SCHEMBL14570561 | 0.85 | NPC1 (0.65) | NPC1RAB9AKDM4EALDH1A1LTA4H | |
| SCHEMBL5442329 | 0.85 | TSHR (0.66) | NPC1RAB9AKDM4EALDH1A1SLC6A2 | |
| SCHEMBL5443488 | 0.85 | ALDH1A1 (0.62) | NPC1RAB9AKDM4EALDH1A1LTA4H | |
| SCHEMBL30186207 | 0.84 | HRH3 (0.81) | SLC6A2SLC6A4LTA4HPDGFRBPDGFRA | |
| SCHEMBL11151279 | 0.84 | HRH3 (0.81) | SLC6A2SLC6A4LTA4HPDGFRBPDGFRA | |
| SCHEMBL15701621 | 0.84 | MEN1 (0.62) | NPC1RAB9AKDM4EALDH1A1LTA4H | |
| SCHEMBL14578276 | 0.83 | ALDH1A1 (0.69) | NPC1RAB9AKDM4EALDH1A1LTA4H | |
| SCHEMBL11274158 | 0.82 | ALDH1A1 (0.62) | NPC1RAB9AKDM4EALDH1A1LTA4H | |
| SCHEMBL6452945 | 0.82 | NPC1 (0.79) | NPC1RAB9AKDM4EALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670787-A4 | CYTOKINE INHIBITORS | KEMIA INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1670787-A2 | CYTOKINE INHIBITORS | Kemia, INC. (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005023761-A2 | CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| EP-1425261-A2 | METHOD FOR PRODUCING 4-AMINO-1-NAPHTHOL ETHERS | Bayer Chemicals AG (DE) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003020686-A2 | METHOD FOR PRODUCING 4-AMINO-1-NAPHTHOL ETHERS | BAYER CHEMICALS AG (DE) | 2003-03-13 | — | — | WO | disclosed |