Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | SMC2 | O95347 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.32 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.32 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040484 | 0.78 | MAP2K1 (0.43) | AAK1SMC2EGFRCSNK2A2MAP2K2 | |
| SCHEMBL1042087 | 0.76 | SMC2 (0.34) | AAK1SMC2EGFRCSNK2A2MAP2K2 | |
| SCHEMBL4421650 | 0.71 | — | — | |
| SCHEMBL12957284 | 0.69 | IMPDH2 (0.35) | IMPDH2 | |
| SCHEMBL27650280 | 0.69 | MAP2K1 (0.38) | AAK1SMC2EGFRCSNK2A2MAP2K2 | |
| SCHEMBL2747756 | 0.62 | MAP2K1 (0.44) | AAK1SMC2EGFRCSNK2A2MAP2K2 | |
| SCHEMBL2280384 | 0.61 | MAP2K1 (0.45) | AAK1SMC2EGFRCSNK2A2MAP2K2 | |
| SCHEMBL1041272 | 0.61 | IDO1 (0.40) | AAK1SMC2EGFRCSNK2A2MAP2K2 | |
| SCHEMBL1038852 | 0.61 | MAP2K1 (0.44) | AAK1SMC2EGFRCSNK2A2MAP2K2 | |
| SCHEMBL3861938 | 0.60 | MAP2K1 (0.39) | AAK1SMC2EGFRCSNK2A2MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130536-A1 | N3 alkylated benzimidazole derivatives as mek inhibitors | Array Biopharma, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |