Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PEPD | P12955 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | XPNPEP2 | O43895 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424333 | 0.94 | ACE (0.55) | ACEKDM4EF2RENLMNA | |
| SCHEMBL14169292 | 0.81 | NPSR1 (0.42) | ACEKDM4EF2RENXPNPEP2 | |
| SCHEMBL14177315 | 0.77 | NPSR1 (0.42) | ACEKDM4EF2XPNPEP2 | |
| SCHEMBL8725597 | 0.77 | ACE (0.53) | ACEKDM4EF2RENLMNA | |
| SCHEMBL31448343 | 0.77 | ACE (0.50) | ACEKDM4EF2RENLMNA | |
| SCHEMBL20681629 | 0.76 | DPP4 (0.61) | ACEKDM4EF2RENLMNA | |
| SCHEMBL20681631 | 0.76 | DPP4 (0.61) | ACEKDM4EF2RENLMNA | |
| SCHEMBL22798445 | 0.76 | DPP4 (0.61) | ACEKDM4EF2RENLMNA | |
| SCHEMBL28660609 | 0.76 | DPP4 (0.61) | ACEKDM4EF2RENLMNA | |
| SCHEMBL27015551 | 0.76 | ACE (0.59) | ACEKDM4EF2RENLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924275-A4 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1924275-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | Simmons, William H. (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007032887-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2007-03-22 | — | — | WO | disclosed |