SCHEMBL442227

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL442976	0.86	HDAC8 (0.53)	HDAC8HDAC6TBXA2R
	SCHEMBL444184	0.84	HDAC8 (0.57)	HDAC8HDAC6TBXA2RADRB3TSHR
	SCHEMBL444530	0.83	HDAC8 (0.56)	HDAC8HDAC6TBXA2R
	SCHEMBL443994	0.82	HDAC8 (0.57)	HDAC8HDAC6TBXA2R
	SCHEMBL446085	0.77	HDAC8 (0.57)	HDAC8HDAC6TBXA2R
	SCHEMBL443399	0.76	HDAC8 (0.59)	HDAC8HPGDSMN1; SMN2
	SCHEMBL445038	0.74	HDAC8 (0.59)	HDAC8HDAC6CA1CA2TSHR
	SCHEMBL444385	0.73	HDAC8 (0.62)	HDAC8HDAC6
	SCHEMBL442226	0.73	HDAC8 (1.00)	HDAC8HDAC6
	SCHEMBL446825	0.72	HDAC8 (0.57)	HDAC8HDAC6TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.