SCHEMBL446085

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL444184	0.88	HDAC8 (0.57)	HDAC8HDAC6TBXA2RALDH1A1
	SCHEMBL445038	0.88	HDAC8 (0.59)	HDAC8HDAC6APOBMTTPLMNA
	SCHEMBL443994	0.84	HDAC8 (0.57)	HDAC8HDAC6TBXA2RPTGDRPTGDR2
	SCHEMBL444530	0.83	HDAC8 (0.56)	HDAC8HDAC6TBXA2R
	SCHEMBL442976	0.82	HDAC8 (0.53)	HDAC8HDAC6TBXA2R
	SCHEMBL443399	0.82	HDAC8 (0.59)	HDAC8ALDH1A1
	SCHEMBL444786	0.78	HDAC8 (0.59)	HDAC8HDAC6TBXA2RLMNA
	SCHEMBL442227	0.77	HDAC8 (0.57)	HDAC8HDAC6TBXA2R
	SCHEMBL445296	0.75	HDAC8 (0.50)	HDAC8HDAC6CYP2C9ALDH1A1
	SCHEMBL447087	0.73	HTR1A (0.38)	HDAC8HDAC6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.