Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802215 | 0.83 | CDK4 (0.35) | TSHRCDK4CCND1PTGER1PTGER4 | |
| SCHEMBL4178701 | 0.83 | TAAR1 (0.40) | TAAR1PTGER4PTGER3PTGER2NFE2L2 | |
| SCHEMBL4178622 | 0.83 | TAAR1 (0.40) | TAAR1PTGER4PTGER3PTGER2NFE2L2 | |
| SCHEMBL4178617 | 0.83 | TAAR1 (0.40) | TAAR1PTGER4PTGER3PTGER2NFE2L2 | |
| SCHEMBL29407427 | 0.78 | ESR1 (0.44) | TSHRTAAR1ESR1ESR2GRM5 | |
| SCHEMBL599914 | 0.78 | ESR1 (0.44) | TSHRTAAR1ESR1ESR2GRM5 | |
| Ammonia Solution, Strong SCHEMBL28176469 | 0.76 | ESR1 (0.43) | TSHRTAAR1ESR1ESR2GRM5 | |
| SCHEMBL16951878 | 0.75 | ALDH1A1 (0.33) | ESR1ESR2GRM5 | |
| SCHEMBL16959608 | 0.75 | DAO (0.35) | ESR1ESR2GRM5 | |
| SCHEMBL8981378 | 0.75 | ALDH1A1 (0.42) | TSHRGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | claimed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | claimed |