Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692155 | 0.80 | POLB (0.47) | POLBHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL27705215 | 0.78 | DHODH (0.43) | ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL9247344 | 0.78 | POLB (0.54) | POLBHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL3062971 | 0.78 | POLB (0.54) | POLBHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL3079333 | 0.76 | POLB (0.52) | POLBHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL3084825 | 0.75 | ALDH1A1 (0.63) | POLBHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL4192188 | 0.75 | NPC1 (0.48) | HPGDNPC1RAB9AALDH1A1GAA | |
| SCHEMBL17674229 | 0.75 | OGG1 (0.56) | ALDH1A1GAAMEN1KMT2ALMNA | |
| SCHEMBL1753793 | 0.75 | IDO1 (0.52) | RAB9AGAAMEN1KMT2AMAOA | |
| SCHEMBL7317371 | 0.75 | CYP2D6 (0.56) | POLBHPGDALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117304135-A | Synthesis method of 4-substituted-5H-1, 2, 3-dithiazole-5-thione and derivative | 衡阳师范学院 | 2023-12-29 | — | — | CN | claimed |
| CN-103109816-A | Thiobenzamide compounds and application thereof | UNIV QINGDAO SCIENCE & TECHNOLOGY | 2013-05-22 | — | — | CN | claimed |
| EP-4584263-A1 | 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND USES THEREOF | Chong Kun Dang Pharmaceutical Corp. (KR) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054071-A1 | 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND USES THEREOF | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2024-03-14 | — | — | WO | disclosed |
| CN-117304135-A | Synthesis method of 4-substituted-5H-1, 2, 3-dithiazole-5-thione and derivative | 衡阳师范学院 | 2023-12-29 | — | — | CN | disclosed |
| CN-111995620-B | Preparation method of 1,3, 4-thiadiazole compound and compound prepared by same | 重庆医科大学 | 2023-06-06 | — | — | CN | disclosed |
| US-20230030414-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2023-02-02 | — | — | US | disclosed |
| EP-4059932-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2022-09-21 | — | — | EP | disclosed |
| EP-3354650-B1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMA (US) | 2022-02-16 | — | — | EP | disclosed |
| US-10961232-B2 | Substituted pyrazines as ATR kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-03-30 | — | — | US | disclosed |
| CN-111995620-A | Preparation method of 1,3, 4-thiadiazole compound and compound prepared by same | 重庆医科大学 | 2020-11-27 | — | — | CN | disclosed |
| US-4423045-A | CARDIOVASCULAR DISORDERS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-12-27 | — | — | US | disclosed |
| US-4401821-A | HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1983-08-30 | — | — | US | disclosed |
| EP-0080296-A1 | Pharmaceutically active phenyl-thia-, oxa- or triazinones | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-01 | — | — | EP | disclosed |
| EP-0019760-B1 | ESTERS OF 3-ARYL-5-METHYL-PYRAZOLE-4-CARBOXYLIC ACID, HERBICIDES CONTAINING THEM, PROCESS FOR THEIR PREPARATION AND THEIR USE | BASF Aktiengesellschaft (DE) | 1982-06-23 | — | — | EP | disclosed |
| EP-0052442-A1 | Heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-05-26 | — | — | EP | disclosed |
| US-4282169-A | FUNGICIDES | OLIN CORPORATION (US) | 1981-08-04 | — | — | US | disclosed |
| EP-0019760-A1 | Esters of 3-aryl-5-methyl-pyrazole-4-carboxylic acid, herbicides containing them, process for their preparation and their use | BASF Aktiengesellschaft (DE) | 1980-12-10 | — | — | EP | disclosed |
| US-4182866-A | CEPHALOSPORINS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-01-08 | — | — | US | disclosed |
| US-4000147-A | ANTICONVULSANTS, CENTRAL NERVOUS SYSTEM DISORDERS | BASF AKTIENGESELLSCHAFT (DT) | 1976-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961232-B2 | Substituted pyrazines as ATR kinase inhibitors | ATR, MAP3K5, CHEK1 | POLB 880/4885HPGD 3310/4885NPC1 4571/4885 |
| US-20230030414-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | POLB 788/4885HPGD 2984/4885NPC1 4192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.