Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007073 | 0.92 | PLA2G7 (0.49) | MAOBHTTPLA2G7NPC1RAB9A | |
| SCHEMBL4415189 | 0.89 | PLA2G7 (0.45) | CTSBMAOBPLA2G7LMNATOP2A | |
| SCHEMBL3545054 | 0.84 | LMNA (0.50) | CTSBMAOBHTTPLA2G7NPC1 | |
| SCHEMBL4949022 | 0.83 | MAOB (0.48) | CTSBMAOBHTTPLA2G7NPC1 | |
| SCHEMBL3537087 | 0.81 | MAOB (0.43) | CTSBMAOBHTTPLA2G7NPC1 | |
| SCHEMBL3545643 | 0.81 | HPGD (0.45) | CTSBMAOBHTTPLA2G7NPC1 | |
| SCHEMBL4420050 | 0.81 | PLA2G7 (0.54) | PLA2G7 | |
| SCHEMBL7557792 | 0.79 | PLA2G7 (0.50) | PLA2G7 | |
| SCHEMBL4416264 | 0.78 | PLA2G7 (0.50) | PLA2G7 | |
| SCHEMBL4953029 | 0.78 | EGFR (0.49) | CTSBMAOBHTTPLA2G7NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |