Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 11/20 | 0.80 |
| ▸ | SLC6A9 | P48067 | 12/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423457 | 1.00 | SLC6A5 (0.80) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL3927563 | 0.91 | SLC6A5 (0.85) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL4422454 | 0.89 | SLC6A5 (0.76) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL5045283 | 0.89 | SLC6A9 (0.94) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL4422974 | 0.89 | SLC6A5 (0.81) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL3921674 | 0.89 | SLC6A5 (0.98) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL3917801 | 0.88 | SLC6A5 (1.00) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL3923755 | 0.88 | SLC6A9 (0.85) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL1689566 | 0.88 | SLC6A5 (1.00) | SLC6A5SLC6A9MAPTPOLBMEN1 | |
| SCHEMBL4424949 | 0.88 | SLC6A5 (0.80) | SLC6A5SLC6A9MAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1703909-B1 | 1-BENZOYL-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | claimed |