Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918954 | 0.88 | TSHR (0.46) | KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL19090603 | 0.87 | SIGMAR1 (0.50) | SIGMAR1KMT2AL3MBTL1MEN1 | |
| SCHEMBL28168201 | 0.86 | SIGMAR1 (0.43) | SIGMAR1KMT2AL3MBTL1MEN1CYP2D6 | |
| SCHEMBL6286870 | 0.82 | SIGMAR1 (0.55) | SIGMAR1 | |
| SCHEMBL918837 | 0.82 | SIGMAR1 (0.46) | SIGMAR1KMT2AL3MBTL1MEN1 | |
| SCHEMBL107901 | 0.82 | SIGMAR1 (0.47) | SIGMAR1 | |
| SCHEMBL10597968 | 0.80 | SIGMAR1 (0.44) | SIGMAR1KMT2AL3MBTL1MEN1CYP2D6 | |
| SCHEMBL7362511 | 0.80 | KCNH2 (0.47) | SIGMAR1CYP2C9CYP2C19 | |
| SCHEMBL9543267 | 0.80 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL921304 | 0.80 | MAOA (0.52) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480984-B9 | HEXACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2009-03-11 | — | — | EP | claimed |
| EP-1480984-B1 | CONDENSED CAMPTOTHECINS AS ANTITUMOR AGENTS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-06-11 | — | — | EP | claimed |
| US-3981871-A | INSECTICIDES | SHELL OIL COMPANY (US) | 1976-09-21 | — | — | US | disclosed |