Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403818 | 0.98 | LMNA (0.48) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| SCHEMBL3227829 | 0.98 | LMNA (0.48) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| SCHEMBL3009609 | 0.98 | LMNA (0.48) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| SCHEMBL5667760 | 0.96 | LMNA (0.46) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| SCHEMBL18585305 | 0.96 | TDP1 (0.50) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| SCHEMBL18585898 | 0.94 | LMNA (0.42) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Ammonia Solution, Strong SCHEMBL15994055 | 0.92 | LMNA (0.40) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| SCHEMBL17571074 | 0.85 | LMNA (0.33) | LMNAL3MBTL1TDP1 | |
| SCHEMBL18585575 | 0.85 | LMNA (0.33) | LMNAL3MBTL1TDP1 | |
| SCHEMBL3748924 | 0.83 | USP2 (0.36) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3223613-B1 | 4-FLUORO-THIO-CONTAINING INHIBITORS OF APP2, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2019-09-04 | — | — | EP | disclosed |
| EP-3223613-A1 | 4-FLUORO-THIO-CONTAINING INHIBITORS OF APP2, COMPOSITIONS THEREOF AND METHOD OF USE | Simmons, William H. (US) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016085530-A1 | 4-FLUORO-THIO-CONTAINING INHIBITORS OF APP2, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2016-06-02 | — | — | WO | disclosed |
| US-9212206-B1 | 4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use | SIMMONS WILLIAM H (US) | 2015-12-15 | — | — | US | disclosed |
| EP-1924275-B1 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-1924275-A4 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2009-07-29 | — | — | EP | disclosed |
| US-7390789-B2 | Thio-containing inhibitors of aminopeptidase P, and compositions thereof | SIMMONS WILLIAM H | 2008-06-24 | — | — | US | disclosed |
| EP-1924275-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | Simmons, William H. (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007032887-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2007-03-22 | — | — | WO | disclosed |
| US-20070060525-A1 | Thio-containing inhibitors of aminopeptidase P, compositions thereof and method of use | SIMMONS WILLIAM H | 2007-03-15 | — | — | US | disclosed |
| EP-0378765-A1 | Antagonists of leukotriene D4 | G.D. Searle & Co. (US) | 1990-07-25 | — | — | EP | disclosed |
| EP-0379191-A1 | 1,3-Dioxolane benzoic acids and derivatives thereof | G.D. Searle & Co. (US) | 1990-07-25 | — | — | EP | disclosed |
| EP-0342664-A2 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | G.D. Searle & Co. (US) | 1989-11-23 | — | — | EP | disclosed |
| US-4870098-A | ANTIALLERGY, ANTIINFLAMMATORY | G. D. SEARLE & CO. (US) | 1989-09-26 | — | — | US | disclosed |
| US-4855324-A | ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0319900-A2 | Furyl, phenylene and thienyl leukotriene B4 analogues | G.D. Searle & Co. (US) | 1989-06-14 | — | — | EP | disclosed |
| EP-0308956-A2 | Leukotriene LTD4 and LTB4 antagonists | G.D. Searle & Co. (US) | 1989-03-29 | — | — | EP | disclosed |
| US-4808729-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0300404-A2 | Di-and tetrahydronapthyl anti-allergy agents | G.D. Searle & Co. (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4791133-A | ANTIINFLAMMATORY AGENTS | G. D. SEARLE & CO. (US) | 1988-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060525-A1 | Thio-containing inhibitors of aminopeptidase P, compositions thereof and method of use | ACE, DNPEP, APP | LMNA 2230/4885L3MBTL1 3545/4885TDP1 1042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.