Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | KMO | O15229 | 5/20 | 0.57 |
| ▸ | EIF4E | P06730 | 6/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412318 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1RXFP1RAB9AKMO | |
| SCHEMBL4423346 | 0.79 | RXFP1 (0.66) | SMN1; SMN2ALDH1A1RXFP1RAB9AKMO | |
| SCHEMBL4429929 | 0.77 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1RXFP1RAB9ADHODH | |
| SCHEMBL2765423 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1RXFP1RAB9ADHODH | |
| SCHEMBL19645881 | 0.75 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1RXFP1RAB9ADHODH | |
| SCHEMBL4427419 | 0.75 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1RXFP1RAB9AKMO | |
| SCHEMBL28330529 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1RXFP1RAB9ADHODH | |
| SCHEMBL1550372 | 0.73 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1RXFP1RAB9ANPC1 | |
| SCHEMBL1939234 | 0.73 | KMO (1.00) | RAB9AKMODHODHNPC1KDM4E | |
| SCHEMBL15441619 | 0.72 | KMO (0.63) | RAB9AKMOEIF4EDHODHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |