Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | RHEB | Q15382 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29801160 | 0.88 | KDM4E (0.48) | MAPK1S1PR4S1PR3KDM4EL3MBTL1 | |
| SCHEMBL24685404 | 0.88 | KDM4E (0.48) | MAPK1S1PR4S1PR3KDM4EL3MBTL1 | |
| SCHEMBL29854237 | 0.88 | KDM4E (0.48) | MAPK1S1PR4S1PR3KDM4EL3MBTL1 | |
| SCHEMBL4412321 | 0.84 | MAPT (0.55) | MAPK1KDM4EL3MBTL1SLC6A3RXFP1 | |
| SCHEMBL29801048 | 0.83 | MAPK1 (0.43) | MAPK1S1PR4S1PR3KDM4EL3MBTL1 | |
| SCHEMBL29854329 | 0.83 | MAPK1 (0.43) | MAPK1S1PR4S1PR3KDM4EL3MBTL1 | |
| SCHEMBL24975201 | 0.83 | MAPK1 (0.43) | MAPK1S1PR4S1PR3KDM4EL3MBTL1 | |
| SCHEMBL29598250 | 0.83 | MAPK1 (0.61) | MAPK1KDM4EL3MBTL1RXFP1HPGDS | |
| SCHEMBL27920850 | 0.81 | HPGDS (0.58) | KDM4EKMORXFP1HPGDSSMN1; SMN2 | |
| SCHEMBL4429958 | 0.80 | KMO (0.69) | NOTUMKDM4EL3MBTL1SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |