Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 14/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699828 | 0.99 | HTR3A (0.52) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL704225 | 0.95 | HTR3A (0.47) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Lithium Ion SCHEMBL699827 | 0.90 | HTR3A (0.52) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL701218 | 0.90 | HTR3A (0.54) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| Lithium Ion SCHEMBL704224 | 0.86 | HTR3A (0.46) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL701688 | 0.86 | HTR3A (0.48) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL4317776 | 0.76 | CHRM2 (0.41) | HTR3A | |
| SCHEMBL700319 | 0.76 | CHRM2 (0.41) | HTR3A | |
| SCHEMBL4316908 | 0.76 | CHRM2 (0.41) | HTR3A | |
| SCHEMBL703142 | 0.75 | CHRM2 (0.41) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155054-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2009-12-23 | — | — | WO | disclosed |