Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.54 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424650 | 0.81 | MCHR1 (0.67) | CD274PDCD1MCHR1SMN1; SMN2MEN1 | |
| SCHEMBL4424496 | 0.80 | HTT (0.51) | CD274PDCD1HDAC1SMN1; SMN2MEN1 | |
| SCHEMBL1549909 | 0.79 | GRM2 (0.49) | SMN1; SMN2STAT3GRM2 | |
| SCHEMBL2263025 | 0.79 | CHRM2 (0.64) | CD274PDCD1MCHR1SMN1; SMN2MEN1 | |
| SCHEMBL4412842 | 0.78 | AURKA (0.47) | HDAC1SMN1; SMN2STAT3GRM2 | |
| SCHEMBL29777000 | 0.78 | KDM4E (0.53) | CD274PDCD1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1633762 | 0.78 | KDM4E (0.53) | CD274PDCD1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL948529 | 0.77 | CHRM2 (0.62) | CD274PDCD1MCHR1SMN1; SMN2MEN1 | |
| SCHEMBL1549465 | 0.74 | GRM2 (0.50) | SMN1; SMN2STAT3GRM2 | |
| SCHEMBL28412589 | 0.73 | OXTR (0.48) | CD274PDCD1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |