Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.68 |
| ▸ | TDP2 | O95551 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.45 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275273 | 0.86 | SRD5A2 (0.66) | HSD17B1SRD5A1SRD5A2HSD17B10CASP1 | |
| SCHEMBL29431442 | 0.86 | SRD5A2 (0.66) | HSD17B1SRD5A1SRD5A2HSD17B10CASP1 | |
| SCHEMBL17540279 | 0.85 | HSD17B1 (0.66) | HSD17B1TDP2CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL28655414 | 0.84 | HSD17B1 (0.78) | HSD17B1CYP1A2CYP11B1CYP11B2HSD17B10 | |
| SCHEMBL1745161 | 0.82 | HSD17B1 (0.71) | HSD17B1TDP2CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL1030949 | 0.81 | HSD17B1 (1.00) | HSD17B1TDP2CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL17400409 | 0.78 | HSD17B1 (0.56) | HSD17B1CYP1A2CYP11B1CYP11B2SRD5A1 | |
| SCHEMBL1747435 | 0.77 | HSD17B1 (0.69) | HSD17B1CYP1A2CYP11B1CYP11B2HSD17B10 | |
| SCHEMBL1746656 | 0.77 | HSD17B1 (0.69) | HSD17B1TDP2CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL1745120 | 0.77 | HSD17B1 (0.69) | HSD17B1CYP1A2CYP11B1CYP11B2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538121-B2 | Vanilloid receptor modulators | GLAXO GROUP LIMITED (GB) | 2009-05-26 | — | — | US | disclosed |
| EP-2033953-A1 | Vanilloid receptor modulators | Glaxo Group Limited (GB) | 2009-03-11 | — | — | EP | disclosed |
| US-20060142333-A1 | Vanilloid receptor modulators | MACDONALD GREGOR J | 2006-06-29 | — | — | US | disclosed |
| EP-1480954-A1 | VANILLOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003068749-A1 | VANILLOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142333-A1 | Vanilloid receptor modulators | TRPV1, NPSR1, TRPV3 | HSD17B1 2536/4885TDP2 4542/4885CYP1A2 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.