Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590494 | 0.88 | MAPK14 (0.45) | MAPK14HDAC1HDAC2PDE4APDE4B | |
| SCHEMBL3589645 | 0.74 | YTHDC1 (0.45) | MAPK14HDAC1HDAC2PDE4APDE4B | |
| SCHEMBL3600409 | 0.68 | MAPK14 (0.40) | MAPK14HDAC1HDAC2PDE4APDE4B | |
| SCHEMBL6482024 | 0.67 | MAPK14 (1.00) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL183179 | 0.66 | ADORA2A (0.62) | HDAC1HDAC2PDE4APDE4BPDE4C | |
| SCHEMBL7204064 | 0.65 | ADORA2A (0.76) | HDAC1HDAC2PDE4APDE4BPDE4C | |
| SCHEMBL7204756 | 0.65 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL2060482 | 0.65 | ADORA2A (0.57) | HDAC1HDAC2PDE4APDE4BPDE4C | |
| SCHEMBL7209426 | 0.64 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPNP | |
| SCHEMBL2060290 | 0.64 | ADORA2A (0.65) | HDAC1HDAC2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132208-A1 | PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NeuroSearch AS (DK) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008116911-A1 | PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-10-02 | — | — | WO | disclosed |