Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6275071 | 0.95 | KDM4E (0.38) | KDM4ENPC1MAPTRAB9ATAS1R3 | |
| SCHEMBL17222397 | 0.91 | KDM4E (0.47) | KDM4ETAS1R3TAS1R1TYMP | |
| SCHEMBL2028468 | 0.85 | ADORA2B (0.38) | ADORA3ADORA2BADORA1 | |
| SCHEMBL7922128 | 0.85 | KDM4E (0.34) | KDM4ETYMP | |
| SCHEMBL6930727 | 0.82 | KDM4E (0.38) | KDM4ETAS1R3TAS1R1TYMPALDH1A1 | |
| SCHEMBL733920 | 0.82 | KDM4E (0.39) | KDM4ETAS1R3TAS1R1 | |
| SCHEMBL7197818 | 0.81 | KDM4E (0.48) | KDM4ETAS1R3TAS1R1TYMP | |
| SCHEMBL12765886 | 0.81 | KDM4E (0.48) | KDM4ETAS1R3TAS1R1TYMP | |
| SCHEMBL17911715 | 0.81 | KDM4E (0.40) | KDM4ETAS1R3TAS1R1TYMP | |
| SCHEMBL6929037 | 0.81 | KDM4E (0.38) | KDM4ETAS1R3TAS1R1TYMPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230193258-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE | 2023-06-22 | — | — | US | disclosed |
| US-11208654-B2 | Methods and compositions for the treatment of cancer or other diseases | CITY OF HOPE (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200032255-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE | 2020-01-30 | — | — | US | disclosed |
| US-10253318-B2 | Methods and compositions for the treatment of cancer or other diseases | CITY OF HOPE (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180142239-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE | 2018-05-24 | — | — | US | disclosed |
| US-9688982-B2 | Methods and compositions for the treatment of cancer or other diseases | CITY OF HOPE (US) | 2017-06-27 | — | — | US | disclosed |
| US-9200279-B2 | Methods and compositions for the treatment of cancer or other diseases | CITY OF HOPE (US) | 2015-12-01 | — | — | US | disclosed |
| US-9200280-B2 | Methods and compositions for the treatment of cancer or other diseases | CITY OF HOPE (US) | 2015-12-01 | — | — | US | disclosed |
| US-20140287987-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE (US) | 2014-09-25 | — | — | US | disclosed |
| US-8748405-B2 | Methods and compositions for the treatment of cancer or other diseases | CITY OF HOPE (US) | 2014-06-10 | — | — | US | disclosed |
| US-20140128324-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140066592-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE (US) | 2014-03-06 | — | — | US | disclosed |
| US-20120065125-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE (US) | 2012-03-15 | — | — | US | disclosed |
| EP-2125855-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20080214436-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE (US) | 2008-09-04 | — | — | US | disclosed |
| WO-2008094254-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | CITY OF HOPE (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214436-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-20120065125-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-20140066592-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-20180142239-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-11208654-B2 | Methods and compositions for the treatment of cancer or other diseases | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-20140287987-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-20200032255-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-20230193258-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-20140128324-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
| US-10253318-B2 | Methods and compositions for the treatment of cancer or other diseases | HLA-DRB1, CD47, IL2 | KDM4E 3701/4885NPC1 798/4885MAPT 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.