Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.59 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.51 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CASR | P41180 | 2/20 | 0.48 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629091 | 1.00 | SIGMAR1 (0.60) | SIGMAR1SLC7A5LOXL2FOLH1CYP4F2 | |
| SCHEMBL15609359 | 1.00 | SIGMAR1 (0.60) | SIGMAR1SLC7A5LOXL2FOLH1CYP4F2 | |
| Hydrochloric Acid SCHEMBL3629090 | 0.99 | SIGMAR1 (0.58) | SIGMAR1SLC7A5LOXL2FOLH1CYP4F2 | |
| Hydrochloric Acid SCHEMBL3629089 | 0.99 | SIGMAR1 (0.58) | SIGMAR1SLC7A5LOXL2FOLH1CYP4F2 | |
| Hydrochloric Acid SCHEMBL11179406 | 0.84 | SIGMAR1 (0.63) | SIGMAR1LOXL2ALDH1A1TSHRADRB1 | |
| Hydrochloric Acid SCHEMBL11233875 | 0.84 | SIGMAR1 (0.63) | SIGMAR1LOXL2ALDH1A1TSHRADRB1 | |
| SCHEMBL4013293 | 0.82 | SIGMAR1 (0.60) | SIGMAR1SLC7A5GPR139ALDH1A1HPGD | |
| SCHEMBL4613121 | 0.82 | SIGMAR1 (0.60) | SIGMAR1SLC7A5GPR139ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3915140 | 0.81 | SIGMAR1 (0.58) | SIGMAR1GPR139NR1I2ADRB1HTR1A | |
| Hydrochloric Acid SCHEMBL4013289 | 0.81 | SIGMAR1 (0.58) | SIGMAR1SLC7A5GPR139ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547731-B2 | Formamide derivatives for the treatment of diseases | PFIZER INC (US) | 2009-06-16 | — | — | US | disclosed |
| US-20080207689-A1 | Formamide Derivatives For The Treatment of Diseases | PFIZER INC | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207689-A1 | Formamide Derivatives For The Treatment of Diseases | FH, FAH, HRH4 | SIGMAR1 4073/4885SLC7A5 1466/4885LOXL2 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.