Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.42 |
| ▸ | ITGAV | P06756 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 9/20 | 0.42 |
| ▸ | CASP3 | P42574 | 3/20 | 0.42 |
| ▸ | CASP7 | P55210 | 3/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431163 | 0.93 | ITGB3 (0.43) | ITGB3ITGAVCASP1GAAITGA2B | |
| SCHEMBL4434014 | 0.92 | ITGB3 (0.42) | ITGB3ITGAVCASP1GAAITGA2B | |
| SCHEMBL4436976 | 0.92 | ITGB3 (0.42) | ITGB3ITGAVCASP1GAAITGA2B | |
| SCHEMBL4427887 | 0.81 | ITGB3 (0.47) | ITGB3ITGAVITGA2BFPR1FPR2 | |
| SCHEMBL4436751 | 0.81 | ITGB3 (0.41) | ITGB3ITGAVCASP1CASP3CASP7 | |
| SCHEMBL7697653 | 0.81 | ITGB3 (0.41) | ITGB3ITGAVCASP1CASP3CASP7 | |
| SCHEMBL4431178 | 0.81 | ITGB3 (0.41) | ITGB3ITGAVCASP1CASP3CASP7 | |
| SCHEMBL4436920 | 0.80 | GAA (0.42) | ITGB3ITGAVCASP1GAAITGA2B | |
| SCHEMBL8506863 | 0.78 | CASP1 (0.41) | CASP1CASP3CASP7CASP8 | |
| SCHEMBL4428449 | 0.78 | ITGB3 (0.42) | ITGB3ITGAVGAAITGA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189881-B2 | PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2013-01-23 | — | — | EP | disclosed |
| EP-1213288-B1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1189881-B1 | PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | TEXAS BIOTECHNOLOGY CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1213288-A1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-06-12 | — | — | EP | disclosed |