SCHEMBL4426587

SCHEMBL4426587

NC(=O)Cn1c(=O)oc2ccc(Br)cc21

nearest known ligand 0.64

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.64
CBX7 O95931 3/20 0.60
CDYL Q9Y232 3/20 0.60
CDY1; CDY1B Q9Y6F8 3/20 0.60
CDYL2 Q8N8U2 2/20 0.60
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
IDO1 P14902 3/20 0.49
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
SIGMAR1 Q99720 1/20 0.46
TP53 P04637 1/20 0.46
NPC1 O15118 1/20 0.45
PDE10A Q9Y233 1/20 0.44
DRD1 P21728 1/20 0.44
KMO O15229 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4411794 0.88 HPGD (0.64) HPGDCBX7CDYLCDY1; CDY1BCDYL2
SCHEMBL5416540 0.87 CBX7 (0.62) CBX7CDYLCDY1; CDY1BCDYL2MEN1
SCHEMBL30660242 0.87 CBX7 (0.62) CBX7CDYLCDY1; CDY1BCDYL2MEN1
SCHEMBL16932296 0.85 CBX7 (0.60) HPGDCBX7CDYLCDY1; CDY1BCDYL2
SCHEMBL30538038 0.85 CBX7 (0.60) HPGDCBX7CDYLCDY1; CDY1BCDYL2
SCHEMBL655852 0.84 HPGD (0.66) HPGDCBX7CDYLCDY1; CDY1BCDYL2
SCHEMBL16250472 0.82 HPGD (0.64) HPGDMEN1KMT2ASMN1; SMN2NPC1
SCHEMBL4427326 0.82 IDO1 (0.71) HPGDMEN1KMT2AIDO1KMO
SCHEMBL29958110 0.82 IDO1 (0.71) HPGDMEN1KMT2AIDO1KMO
SCHEMBL25866126 0.81 CBX7 (0.55) HPGDCBX7CDYLCDY1; CDY1BCDYL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8293775-B2 Benzoxazolone derivatives, processes for preparing them and their uses UCB PHARMA, S.A. (BE) 2012-10-23 US disclosed
EP-1756071-B1 BENZOXAZOLONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB PHARMA SA (BE) 2009-08-26 EP disclosed
US-20070299118-A1 Benzoxazolone Derivatives, Processes For Preparing Them And Their Uses UCB, S.A. (BE) 2007-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070299118-A1 Benzoxazolone Derivatives, Processes For Preparing Them And Their Uses PARK7, SNCA, GABRA5 HPGD 232/4885CBX7 334/4885CDYL 2044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.