Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.79 |
| ▸ | THRA | P10827 | 18/20 | 0.79 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430417 | 0.89 | THRB (1.00) | THRBTHRA | |
| SCHEMBL4432776 | 0.87 | THRB (0.95) | THRBTHRA | |
| SCHEMBL2790015 | 0.87 | THRB (1.00) | THRBTHRA | |
| SCHEMBL4432145 | 0.86 | THRB (0.83) | THRBTHRA | |
| SCHEMBL4426123 | 0.86 | THRB (0.89) | THRBTHRA | |
| SCHEMBL4424841 | 0.86 | THRB (0.83) | THRBTHRA | |
| SCHEMBL22229872 | 0.85 | EPHX1 (0.68) | THRBTHRAEPHX1EPHX2 | |
| SCHEMBL2786318 | 0.84 | THRB (1.00) | THRBTHRA | |
| SCHEMBL2785270 | 0.83 | THRB (1.00) | THRBTHRA | |
| SCHEMBL4434653 | 0.82 | THRB (0.76) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557143-B2 | Thyroid receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-07 | — | — | US | claimed |