SCHEMBL4432145

SCHEMBL4432145

O=C(O)Cc1cc(Cl)c(Oc2ccc(O)c(-c3ccc(F)cc3)c2)c(Cl)c1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 20/20 0.83
THRA P10827 19/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4430417 0.91 THRB (1.00) THRBTHRA
SCHEMBL4432776 0.89 THRB (0.95) THRBTHRA
SCHEMBL2790015 0.89 THRB (1.00) THRBTHRA
SCHEMBL4424841 0.88 THRB (0.83) THRBTHRA
SCHEMBL4426123 0.88 THRB (0.89) THRBTHRA
SCHEMBL4427531 0.88 THRB (0.80) THRBTHRA
SCHEMBL2785270 0.88 THRB (1.00) THRBTHRA
SCHEMBL4427103 0.86 THRB (0.79) THRBTHRA
SCHEMBL2786318 0.86 THRB (1.00) THRBTHRA
SCHEMBL2785215 0.85 THRB (0.65) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7557143-B2 Thyroid receptor ligands BRISTOL-MYERS SQUIBB COMPANY (US) 2009-07-07 US claimed