Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429125 | 1.00 | MAOB (0.44) | MAOBPARP10MRGPRX4HDAC1HDAC8 | |
| SCHEMBL4424328 | 0.89 | MRGPRX4 (0.53) | MAOBMRGPRX4PPARG | |
| SCHEMBL4422912 | 0.89 | MRGPRX4 (0.53) | MAOBMRGPRX4PPARG | |
| SCHEMBL4422233 | 0.88 | MRGPRX4 (0.49) | MAOBPARP10MRGPRX4SCN9A | |
| SCHEMBL4422239 | 0.88 | MRGPRX4 (0.49) | MAOBPARP10MRGPRX4SCN9A | |
| SCHEMBL4423323 | 0.85 | MAOB (0.45) | MAOBPARP10HDAC1HDAC8HDAC6 | |
| SCHEMBL4423318 | 0.85 | MAOB (0.45) | MAOBPARP10HDAC1HDAC8HDAC6 | |
| SCHEMBL5811691 | 0.80 | MAOB (0.44) | MAOBPARP10HDAC1HDAC8HDAC6 | |
| SCHEMBL4427215 | 0.80 | MAOB (0.46) | MAOBPARP10HDAC1MEN1KMT2A | |
| SCHEMBL3505057 | 0.80 | MAOB (0.46) | MAOBPARP10HDAC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515926-B1 | FLUOROBENZAMIDES SUITABLE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SENILE DEMENTIA | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | EP | claimed |
| US-20070078172-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2007-04-05 | — | — | US | claimed |
| WO-2006138475-A2 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2006-12-28 | — | — | WO | claimed |
| US-6951884-B2 | Fluorobenzamides and uses thereof | HOFFMANN-LA ROCHE INC. (US) | 2005-10-04 | — | — | US | claimed |
| EP-1515926-A2 | FLUOROBENZAMIDES SUITABLE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SENILE DEMENTIA | F.HOFFMANN-LA ROCHE AG (CH) | 2005-03-23 | — | — | EP | claimed |
| US-20030236304-A1 | Fluorobenzamides and uses thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-25 | — | — | US | claimed |
| WO-2003106380-A2 | FLUOROBENZAMIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2003-12-24 | — | — | WO | claimed |
| EP-1515926-B1 | FLUOROBENZAMIDES SUITABLE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SENILE DEMENTIA | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | EP | disclosed |
| US-20070078172-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2007-04-05 | — | — | US | disclosed |
| WO-2006138475-A2 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2006-12-28 | — | — | WO | disclosed |
| US-6951884-B2 | Fluorobenzamides and uses thereof | HOFFMANN-LA ROCHE INC. (US) | 2005-10-04 | — | — | US | disclosed |
| EP-1515926-A2 | FLUOROBENZAMIDES SUITABLE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SENILE DEMENTIA | F.HOFFMANN-LA ROCHE AG (CH) | 2005-03-23 | — | — | EP | disclosed |
| US-20030236304-A1 | Fluorobenzamides and uses thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-25 | — | — | US | disclosed |
| WO-2003106380-A2 | FLUOROBENZAMIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236304-A1 | Fluorobenzamides and uses thereof | MAOB, MAOA, BCHE | MAOB 1/4885PARP10 1686/4885MRGPRX4 1009/4885 |
| US-20070078172-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | MAOB, MAOA, GPR119 | MAOB 1/4885PARP10 833/4885MRGPRX4 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.