Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL234386 | 0.84 | LMNA (0.34) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL1684840 | 0.84 | DNMT1 (0.34) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL17748439 | 0.82 | LMNA (0.33) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL6241745 | 0.81 | LMNA (0.35) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL20500065 | 0.81 | LMNA (0.33) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL27908324 | 0.81 | PDE4D (0.33) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL27090390 | 0.80 | LMNA (0.34) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL4414286 | 0.78 | LMNA (0.51) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL18007504 | 0.78 | ADORA2A (0.31) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 | |
| SCHEMBL6914466 | 0.78 | LMNA (0.31) | LMNAMTORSMN1; SMN2ALDH1A1DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804821-A4 | HCV NS3-NS4A PROTEASE INHIBITION | VERTEX PHARMA (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1804821-A2 | HCV NS3-NS4A PROTEASE INHIBITION | Vertex Pharmaceuticals, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006039488-A2 | HCV NS3-NS4A PROTEASE INHIBITION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-04-13 | — | — | WO | disclosed |