Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16345385 | 0.73 | FGFR1 (0.55) | TSHRGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2896391 | 0.72 | CYP1A2 (0.50) | TSHRGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10796231 | 0.72 | CA12 (0.52) | TSHRGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4986643 | 0.71 | OPRD1 (0.47) | TSHRPPARAGAAL3MBTL1ALDH1A1 | |
| SCHEMBL4433925 | 0.71 | TSHR (0.46) | TSHRPPARAGAAL3MBTL1ALDH1A1 | |
| SCHEMBL14972272 | 0.70 | MAPK1 (0.50) | TSHRPPARAGAAL3MBTL1ALDH1A1 | |
| SCHEMBL14967035 | 0.70 | MAPK1 (0.50) | TSHRPPARAGAAL3MBTL1ALDH1A1 | |
| SCHEMBL22579467 | 0.70 | CA12 (0.46) | TSHRGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL27878777 | 0.67 | TSHR (0.68) | TSHRGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL22556827 | 0.67 | AR (0.43) | TSHRGAAL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |