Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429426 | 0.83 | KMT2A (0.40) | TSHRPARP1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL2586738 | 0.79 | CYP1A2 (0.46) | TSHRPARP1PDE2AGAAALDH1A1 | |
| SCHEMBL731835 | 0.75 | TSHR (0.50) | TSHRPARP1PDE2AGAARAB9A | |
| SCHEMBL14966528 | 0.74 | HSD17B10 (0.46) | TSHRPDE2AGAAALDH1A1L3MBTL1 | |
| SCHEMBL14967358 | 0.73 | GPR84 (0.58) | TSHRALDH1A1LMNAHPGD | |
| SCHEMBL4431487 | 0.72 | KDM4E (0.54) | TSHRGAAALDH1A1RAB9AHSD17B10 | |
| SCHEMBL4428229 | 0.71 | TSHR (0.46) | TSHRPPARAGAAALDH1A1L3MBTL1 | |
| SCHEMBL2897844 | 0.70 | KDM4E (0.51) | TSHRPARP1GAAALDH1A1L3MBTL1 | |
| SCHEMBL17112576 | 0.68 | CYP1A2 (0.49) | TSHRPARP1GAAALDH1A1L3MBTL1 | |
| SCHEMBL13545931 | 0.67 | ESR1 (0.72) | TSHRGAAALDH1A1L3MBTL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |