Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438805 | 0.84 | HSD17B2 (0.48) | HSD17B2KDM4EPDE2A | |
| SCHEMBL4427252 | 0.82 | KDM4E (0.53) | HSD17B2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14931973 | 0.75 | KDM4E (0.66) | HSD17B2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4429520 | 0.74 | KDM4E (0.42) | HSD17B2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4439660 | 0.73 | KDM4E (0.41) | KDM4ECES2CES1MEN1KMT2A | |
| SCHEMBL3071414 | 0.73 | KDM4E (0.49) | HSD17B2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4379536 | 0.71 | KDM5A (0.54) | HSD17B2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4430946 | 0.70 | HSD17B2 (0.46) | HSD17B2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5124119 | 0.70 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL3077344 | 0.70 | HSD17B2 (0.52) | HSD17B2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |