Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 2/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438725 | 0.84 | DAO (0.55) | KDM5AKDM4CKDM5BDAODHODH | |
| SCHEMBL3917621 | 0.84 | DAO (0.46) | KDM5AKDM4CKDM5BDAOKDM4E | |
| SCHEMBL11836193 | 0.82 | KDM4E (0.42) | KDM5AKDM4CKDM5BDAOKDM4E | |
| SCHEMBL4428237 | 0.82 | KDM4E (0.50) | KDM5AKDM4CKDM5BDAOKDM4E | |
| SCHEMBL3912930 | 0.82 | KDM4E (0.53) | KDM5AKDM4CKDM5BDAOKDM4E | |
| SCHEMBL3920671 | 0.81 | DAO (0.54) | KDM4CKDM5BDAOKDM4EALDH1A1 | |
| SCHEMBL4430485 | 0.81 | KDM4E (0.41) | KDM5AKDM4CKDM5BDAOKDM4E | |
| SCHEMBL4433258 | 0.79 | KDM4E (0.55) | KDM5AKDM4CKDM5BKDM4EALDH1A1 | |
| SCHEMBL4372824 | 0.77 | KDM5A (0.55) | KDM5AKDM4CKDM5BDAOKDM4E | |
| SCHEMBL11835232 | 0.77 | KDM4E (0.59) | KDM5AKDM5BDAOKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |