Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.54 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.54 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505966 | 0.90 | MAOB (0.63) | SPHK2PARP10PARP15SPHK1MAOB | |
| SCHEMBL3506405 | 0.90 | MAOB (0.65) | SPHK2PARP10PARP15MAOBMAOA | |
| SCHEMBL4428735 | 0.84 | PARP15 (0.45) | SPHK2PARP10PARP15MAOBMAOA | |
| SCHEMBL4426077 | 0.82 | MEN1 (0.58) | SPHK2NOX1SPHK1MEN1NPC1 | |
| SCHEMBL4432758 | 0.82 | ALDH1A1 (0.58) | PARP10PARP15NOX1MEN1NPC1 | |
| SCHEMBL2997270 | 0.81 | MAOB (0.62) | PARP10PARP15NOX1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9015457 | 0.80 | MAOB (0.61) | PARP10PARP15NOX1MEN1KMT2A | |
| SCHEMBL27683488 | 0.80 | MAOB (0.61) | PARP10PARP15NOX1MEN1KMT2A | |
| SCHEMBL5808180 | 0.79 | MAOB (0.60) | SPHK2PARP10PARP15MEN1NPC1 | |
| SCHEMBL5806883 | 0.78 | MAOB (0.63) | PARP10PARP15MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951884-B2 | Fluorobenzamides and uses thereof | HOFFMANN-LA ROCHE INC. (US) | 2005-10-04 | — | — | US | claimed |
| US-20030236304-A1 | Fluorobenzamides and uses thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-25 | — | — | US | claimed |
| EP-1515926-B1 | FLUOROBENZAMIDES SUITABLE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SENILE DEMENTIA | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | EP | disclosed |
| CN-1274669-C | Fluorobenzamides suitable for the treatment of alzheimer's disease or senile dementia | HOFFMANN LA ROCHE (CH) | 2006-09-13 | — | — | CN | disclosed |
| US-6951884-B2 | Fluorobenzamides and uses thereof | HOFFMANN-LA ROCHE INC. (US) | 2005-10-04 | — | — | US | disclosed |
| CN-1659135-A | Fluorobenzamides suitable for the treatment of alzheimer's disease or senile dementia | HOFFMANN LA ROCHE (CH) | 2005-08-24 | — | — | CN | disclosed |
| US-20030236304-A1 | Fluorobenzamides and uses thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236304-A1 | Fluorobenzamides and uses thereof | MAOB, MAOA, BCHE | SPHK2 2586/4885PARP10 1686/4885PARP15 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.