Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2689523 | 0.69 | — | — | |
| SCHEMBL6192821 | 0.65 | — | — | |
| SCHEMBL21247206 | 0.65 | — | — | |
| SCHEMBL2904914 | 0.65 | — | — | |
| SCHEMBL108518 | 0.65 | — | — | |
| SCHEMBL1238782 | 0.62 | CA1 (0.38) | CA1CA2CA4 | |
| SCHEMBL24410787 | 0.62 | TP53 (0.35) | MAPTCYP3A4 | |
| SCHEMBL2691037 | 0.62 | CYP3A4 (0.41) | MAPTCYP3A4CA1CA2CA4 | |
| SCHEMBL4009745 | 0.62 | — | — | |
| SCHEMBL20100996 | 0.62 | CYP3A4 (0.41) | MAPTCYP3A4CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598384-B2 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-10-06 | — | — | US | disclosed |
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | disclosed |
| EP-1723116-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co. KGaA (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082856-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-09 | — | — | WO | disclosed |
| US-20050197361-A1 | Specific binding is extremely high; low toxicity; high degree of activity; 2-(5-m-Tolyl-thiazol-2-yl )-7,8-dihydro-6H-quinolin-5-one, acute and/or chronic neurological disorders | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-08 | — | — | US | disclosed |
| US-6756343-B1 | CONTROLLING RICE PADDY FIELD WEEDS AT LOW DOSAGE DOSE; PLANT SAFENING | IDEMITSU KOSAN CO., LTD. (JP) | 2004-06-29 | — | — | US | disclosed |
| US-20040002425-A1 | Triketone derivatives and herbicides | IDEMITSU KOSAN CO., LTD. (JP) | 2004-01-01 | — | — | US | disclosed |
| EP-1120413-A1 | TRIKETONE DERIVATIVE AND HERBICIDE | IDEMITSU KOSAN COMPANY LIMITED (JP) | 2001-08-01 | — | — | EP | disclosed |
| US-5306695-A | Haloalkoxy-substituted benzoylcyclohexanediones as herbicides and plant growth regulators | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-26 | — | — | US | disclosed |
| EP-0502492-A2 | Haloalkoxy-substituted benzoylcyclohexanediones as herbicides and plant growth regulators | Hoechst Schering AgrEvo GmbH (DE) | 1992-09-09 | — | — | EP | disclosed |
| US-4946981-A | HERBICIDES | ICI AMERICAS INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4853028-A | Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones | STAUFFER CHEMICAL COMPANY (US) | 1989-08-01 | — | — | US | disclosed |
| US-4822906-A | HERBICIDE INTERMEDIATE | STAUFFER CHEMICAL COMPANY (US) | 1989-04-18 | — | — | US | disclosed |
| US-4816066-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| US-4806146-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0186120-B1 | CERTAIN-2-(2'-ALKYLBENZOYL)-1,3-CYCLOHEXANEDIONES | STAUFFER CHEMICAL COMPANY (US) | 1988-11-23 | — | — | EP | disclosed |
| US-4780127-A | Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides | STAUFFER CHEMICAL COMPANY (US) | 1988-10-25 | — | — | US | disclosed |
| US-4695673-A | Process for the production of acylated 1,3-dicarbonyl compounds | STAUFFER CHEMICAL COMPANY (US) | 1987-09-22 | — | — | US | disclosed |
| EP-0186120-A1 | Certain-2-(2'-alkylbenzoyl)-1,3-cyclohexanediones | STAUFFER CHEMICAL COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| EP-0186117-A2 | Process for the production of acylated diketonic compounds | STAUFFER CHEMICAL COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002425-A1 | Triketone derivatives and herbicides | SYMPK, STK36, STK32A | MAPT 2107/4885CYP3A4 1446/4885CA1 2942/4885 |
| US-20050197361-A1 | Specific binding is extremely high; low toxicity; high degree of activity; 2-(5-m-Tolyl-thiazol-2-yl )-7,8-dihydro-6H-quinolin-5-one, acute and/or chronic neurological disorders | GRM5, GRIK5, GRIN2C | MAPT 882/4885CYP3A4 2398/4885CA1 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.