Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427049 | 0.84 | KDM4E (0.64) | MDM2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL4437640 | 0.81 | KDM4E (0.68) | MDM2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9260068 | 0.80 | MDM2 (0.54) | MDM2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL4429820 | 0.79 | KDM4E (0.93) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL1222162 | 0.78 | LMNA (0.55) | MDM2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6110541 | 0.77 | TSHR (0.56) | KDM4EALDH1A1GAASMN1; SMN2TSHR | |
| SCHEMBL14252251 | 0.76 | TSHR (0.65) | KDM4EALDH1A1GAASMN1; SMN2TSHR | |
| SCHEMBL8121938 | 0.76 | ALDH1A1 (0.60) | MDM2KDM4EALDH1A1GAATSHR | |
| SCHEMBL1156069 | 0.75 | BRD4 (0.63) | MDM2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL4074628 | 0.75 | KDM4E (1.00) | MDM2KDM4EALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |