Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4432359 | 0.89 | ALOX5 (0.43) | ALOX5CYP2D6HDAC6GRM2GRM3 | |
| SCHEMBL10323234 | 0.78 | KDM5A (0.40) | ALOX5CYP2D6SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL16054265 | 0.77 | ALOX5 (0.47) | ALOX5CYP2D6 | |
| SCHEMBL10323213 | 0.77 | KDM5A (0.41) | ALOX5CYP2D6SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL30662232 | 0.77 | ALOX5 (0.37) | ALOX5 | |
| SCHEMBL27843733 | 0.75 | ALOX5 (0.48) | ALOX5CYP2D6EPHX1HPGDKMT2A | |
| SCHEMBL5305672 | 0.74 | HDAC1 (0.51) | ALOX5HDAC1HDAC6KMT2A | |
| SCHEMBL3599049 | 0.74 | KDM5A (0.46) | ALOX5CYP2D6EPHX1HPGDKDM5A | |
| SCHEMBL3588549 | 0.74 | KDM5A (0.47) | ALOX5EPHX1KDM5AKDM4CPHF8 | |
| SCHEMBL5300153 | 0.73 | HDAC1 (0.53) | ALOX5HDAC1HDAC6EPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118106-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | claimed |
| WO-2008107368-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | claimed |
| EP-2118106-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008107368-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |