Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441220 | 0.94 | KDM4E (0.43) | CCR2TACR1ALOX5EPHX2KDM4E | |
| SCHEMBL4433024 | 0.94 | KDM4E (0.43) | CCR2TACR1ALOX5EPHX2KDM4E | |
| SCHEMBL4434946 | 0.86 | P2RX7 (0.41) | CCR2TACR1EPHX2 | |
| SCHEMBL4440232 | 0.86 | P2RX7 (0.41) | CCR2TACR1EPHX2 | |
| SCHEMBL4438661 | 0.83 | KDM4E (0.45) | CCR2TACR1KDM4EALDH1A1CTDSP1 | |
| SCHEMBL4440273 | 0.83 | KDM4E (0.45) | CCR2TACR1KDM4EALDH1A1CTDSP1 | |
| SCHEMBL4427927 | 0.82 | CNR1 (0.51) | CCR2TACR1ALOX5EPHX2KDM4E | |
| SCHEMBL4434552 | 0.82 | CNR1 (0.51) | CCR2TACR1ALOX5EPHX2KDM4E | |
| SCHEMBL4428071 | 0.81 | KDM4E (0.48) | CCR2TACR1ALOX5EPHX2KDM4E | |
| SCHEMBL4441795 | 0.81 | KDM4E (0.46) | CCR2TACR1ALOX5EPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |