Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442168 | 0.88 | HSD11B1 (0.40) | HSD11B1NR1H2NR1H3CTSAKDM4E | |
| SCHEMBL27802800 | 0.88 | HSD11B1 (0.40) | HSD11B1NR1H2NR1H3CTSAPIK3CD | |
| SCHEMBL4173848 | 0.85 | HSD11B1 (0.41) | HSD11B1NR1H2NR1H3CTSAPIK3CD | |
| SCHEMBL14047492 | 0.85 | HSD11B1 (0.41) | HSD11B1NR1H2NR1H3CTSAKDM4E | |
| SCHEMBL4433997 | 0.82 | HSD11B1 (0.40) | HSD11B1KDM4EALDH1A1KMT2A | |
| SCHEMBL4178245 | 0.81 | DPP4 (0.42) | HSD11B1DPP4MPLP2RX7 | |
| SCHEMBL16585330 | 0.80 | KDM4E (0.46) | MAOBTAAR1DPP4KDM4EALDH1A1 | |
| SCHEMBL4177857 | 0.80 | HSD11B1 (0.48) | HSD11B1NR1H2KDM4EALDH1A1GLA | |
| SCHEMBL27781199 | 0.79 | HSD11B1 (0.37) | HSD11B1CTSADPP4KDM4EP2RX7 | |
| SCHEMBL4182193 | 0.77 | HSD11B1 (0.40) | HSD11B1CTSAPIK3CDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |