Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429900 | 0.82 | HSD11B1 (0.40) | HSD11B1ALDH1A1KDM4EKMT2A | |
| SCHEMBL27802800 | 0.82 | HSD11B1 (0.40) | HSD11B1ALDH1A1KDM4EKMT2A | |
| SCHEMBL4442168 | 0.82 | HSD11B1 (0.40) | HSD11B1ALDH1A1KDM4EKMT2A | |
| SCHEMBL4173848 | 0.80 | HSD11B1 (0.41) | HSD11B1ALDH1A1KDM4EKMT2A | |
| SCHEMBL14047492 | 0.80 | HSD11B1 (0.41) | HSD11B1ALDH1A1KDM4EKMT2A | |
| SCHEMBL15319751 | 0.76 | PDE10A (0.44) | ALDH1A1PDE10AMAPTPKMLMNA | |
| SCHEMBL4174007 | 0.76 | HSD11B1 (0.39) | HSD11B1MAPTKMT2A | |
| SCHEMBL27781199 | 0.76 | HSD11B1 (0.37) | HSD11B1KDM4E | |
| SCHEMBL4177857 | 0.75 | HSD11B1 (0.48) | HSD11B1ALDH1A1PDE10AMAPTKDM4E | |
| SCHEMBL4178180 | 0.73 | HSD11B1 (0.39) | HSD11B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |