Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 1/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.51 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.51 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | CCR3 | P51677 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389715 | 0.91 | SLC6A12 (0.62) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL3665894 | 0.88 | PRKAA2 (0.56) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL4434196 | 0.87 | PRKAA2 (0.51) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3663596 | 0.85 | PRKAA2 (0.49) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL2389022 | 0.85 | SLC6A12 (0.58) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL12226320 | 0.81 | SLC6A12 (0.68) | SLC6A12CYP3A4HRH3KCNH2 | |
| SCHEMBL4441461 | 0.81 | KMT2A (0.64) | SLC6A12CYP3A4CCR3 | |
| SCHEMBL2389604 | 0.78 | KMT2A (0.65) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL15171728 | 0.78 | CCR3 (0.62) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL61347 | 0.78 | DRD4 (0.66) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079694-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | Rigel Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008083124-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | WO | claimed |