Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 13/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.51 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.51 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2390055 | 0.90 | MCHR1 (0.59) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3665894 | 0.87 | PRKAA2 (0.56) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL4429910 | 0.87 | SLC6A12 (0.51) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3663596 | 0.82 | PRKAA2 (0.49) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL4429895 | 0.81 | UTS2R (0.65) | MEN1KMT2AMCHR1UTS2R | |
| SCHEMBL2390761 | 0.81 | UTS2R (0.65) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL4441461 | 0.81 | KMT2A (0.64) | CYP3A4MEN1KMT2AMCHR1 | |
| SCHEMBL2388559 | 0.80 | DRD4 (0.63) | CYP3A4MEN1KMT2AMCHR1UTS2R | |
| SCHEMBL12227457 | 0.80 | KMT2A (0.61) | CYP3A4MEN1KMT2AMCHR1UTS2R | |
| SCHEMBL4435309 | 0.79 | POLB (0.61) | MEN1KMT2AMCHR1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079694-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | Rigel Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008083124-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | WO | claimed |