Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968056 | 0.89 | TDP1 (0.54) | GRM2TDP1NPC1RAB9A | |
| SCHEMBL1513569 | 0.86 | TDP1 (0.45) | GRM2TDP1NPC1RAB9ALTA4H | |
| SCHEMBL1513567 | 0.86 | TDP1 (0.45) | GRM2TDP1NPC1RAB9ALTA4H | |
| SCHEMBL7831157 | 0.83 | GRM2 (0.52) | GRM2TDP1 | |
| SCHEMBL3139586 | 0.81 | MEN1 (0.64) | GRM2TDP1 | |
| SCHEMBL3144448 | 0.81 | GRM2 (0.49) | GRM2TDP1NPC1RAB9A | |
| SCHEMBL1513808 | 0.80 | TSHR (0.41) | GRM2TDP1 | |
| SCHEMBL1513582 | 0.80 | TSHR (0.41) | GRM2TDP1 | |
| SCHEMBL3144268 | 0.80 | ALOX5 (0.39) | GRM2TDP1LTA4H | |
| SCHEMBL3135510 | 0.80 | GRM2 (0.50) | GRM2NPC1RAB9ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |